The City of Frontenac eclipses two public school districts; the majority of homes are in the Ladue School, while some homes in the southern side of Frontenac are in the Kirkwood School District. In addition, the Saul Mirowitz-Reform Jewish Academy Day School, at B’Nai El Temple, and two private all girls' schools, Villa Duchene and St. Joseph's Academy, are both located within Frontenac.

Also within in the City’s borders are the Church of the Latter Day Saints, Faith & Des Peres Presbyterian Church, and B'Nai El Temple. The City lies between two Catholic Parishes, Our Lady of the Pillar in Creve Coeur and Saint Clement in Des Peres. The Novitiate of the Sisters of Mercy Center is also in Frontenac.